Stephanie Beatriz plays Gina, BoJack's co-star/love interest who plays BoJack's co-star/love interest on the fictional television show Philbert. The thin line between fiction and real life may be iffy in this relationship, but it also allows BoJack the opprotunity to be a better partner to her than he's been to his past partners. Beatriz is no stranger to comedy, but her role in Bojack shows that she can handle dramatic material just as well.

Rami Malek plays Philbert Showrunner Flip Mcvicker, who is so blinded by his artistic vision that he seems to be the only person who can't see that Philbert isn't a great show. Malek is most associated with the no-nonsense role of Elliot Alderson on Mr. Robot, making this goofy caricature a welcome change of pace for the Emmy-winning actor.

Hong Chau, known for her Golden Globe-nominated role in Downsizing, takes one of the largest guest-starring roles of the season, portraying Pickles, Mr. Peanutbutter's new girlfriend. A young, enthusiastic waitress and "aspiring social media influencer," Pickles represents a stark change from Mr. Peanutbutter's last partner, Diane — but is this change for better or worse?

Whoopi Goldberg, certified EGOT recipient, makes a small appearence in the series as Mikayla, a stork that works for an adoption agency — get it? — and sells Princess Carolyn on their adoption agency before handing her off to someone who is less enthusiastic and is not voiced by EGOT recipient Whoopi Goldberg.

Star of The Grinder and Santa Clarita Diet Natalie Morales plays Yolanda Buenaventura, Asexual Axolotl and Todd's girlfriend. The two form a bond over their shared identity and the fact that they are asexual but not aromantic, but the jobless, directionless Todd may need to get his life in shape if he wants to find a way to make their relationship work.

Following in the footsteps of Jessica Biel, who played a fictionalized version of herself on BoJack Horseman starting in Season 3, Laura Linney stops by the show to portray and exageratted version of herself as she films a new movie in Vietnam and ends up running into Diane while she's visiting the country.

Insecure's creator and star Issa Rae lends her voice to the role of Diane's therapist, who attempts to help Diane find ways to life a better life following the dissolution of her marriage to Mr. Peanutbutter. Rae has expressed her love of the show in the past, telling The Los Angeles Times, "It’s supposed to be a cartoon, but it draws you in. It’s dark and so good."

Comedian extraordinaire Wanda Sykes makes an appearance as the wife of Diane's therapist, a lawyer who works in corporate mediation and enjoys sharing confidential stories of all the famous celebrities they work with. While they have a lot to say about Princess Carolyn, they're forced to speak in codenames as to not break confidentiality.

Star of stage and screen John Leguizamo plays the role of Yolanda the Asexual Axlotol’s father, who grills his daughter and her boyfriend, Todd, during a family dinner. While Todd may imagine that it won't be heard to relate to his partner's father, the fact that Yolanda's father is an esteemed erotic novelist who wants to talk about sexuality complicates the mater.

If Yolanda's erotic novelist father may prove to be difficult for an asexual couple to relate to, Yolanda's mother will prove to be even more cumbersome. Yolanda's mother, voiced by Eva Longoria, is an esteemed star of adult films, a role that Eva Longoria may be familiar with judging by her 2007 video for FunnyOrDie.com, EVA LONGORIA SEX TAPE.

Ant-Man and Will & Grace star Bobby Cannavale plays Vance Waggoner, a movie star whose behavior ranges from the violent to the unexcusable, spouting of sexist and anti-Semitic language and threatening his own daughter with death over voicemail. Naturally, he attempts to stage a comeback and tries to put his past behind him — almost as if Vance Waggoner were a continuation of Cannavale's Master Of None character who was discovered to be harassing women.

Angela Bassett returns to BoJack as Ana Spanikopita, BoJack's former publicist and romantic partner from Season 3. In Season 5 she takes on the role of publicist for another man with a problematic past, Vance Waggoner. Spanikopita's calculated approach to Waggoner's public rehabilitation doesn't reunite her with BoJack, but it does lead to some confrontations with Diane.

Atlanta star Brian Tyree Henry appears as Cooper, who plays a crucial role in Princess Carolyn's past. Princess Caroline's history comes back to haunt her when she visits her hometown. As a child, she has an affair with Cooper Thomas Rogers Wallace, the son of the family she is a maid for, and ends up pregnant.

Daveed Diggs, Tony-winning star of Hamilton, and his distinctive voice appear for a brief scene during Princess Caroline's return to her hometown. He gives voice to Cooper Thomas Rogers Wallace's father, who is also named Cooper Thomas Rogers Wallace, as he attempts to introduce Princess Carolyn into their life and make a plan for his grandchild.

After being completely absent from Season 4 of BoJack Horseman, perhaps the must chaotic recurring guest star in the show's history returns to the show. Beloved Character Actress Margo Martindale, played by Beloved Character Actress Margo Martindale Margo Martindale, has gotten up to some impressive mischief in the past, but fans will be seeing her in a much different light in Season 5.

The guest stars of BoJack Horseman are plentiful, and the presences of real life celebrities — whether they're playing themselves or fictional characters — helps make the world of Hollywoo seem that much more believable. Where else would you see a show where the hacker of Mr. Robot directs a tv show starring Rosa Diaz?